• Anesthesia and analgesia · Jul 2012

    Systemic inflammatory response does not correlate with acute lung injury associated with mechanical ventilation strategies in normal lungs.

    • Caron M Hong, Da-Zhong Xu, Vadim Pisarenko, Danielle Doucet, Margaret Brown, Edwin A Deitch, and Ellise Delphin.
    • Department of Anesthesiology, University of Maryland, 22 S. Greene St., S11C, Baltimore, MD 21201, USA. chong@anes.umm.edu
    • Anesth. Analg.. 2012 Jul 1;115(1):118-21.

    BackgroundMechanical ventilation (MV) can lead to ventilator-induced lung injury secondary to trauma and associated increases in pulmonary inflammatory cytokines. There is controversy regarding the associated systemic inflammatory response. In this report, we demonstrate the effects of MV on systemic inflammation.MethodsThis report is part of a previously published study (Hong et al. Anesth Analg 2010;110:1652-60). Female pigs were randomized into 3 groups. Group H-Vt/3 was ventilated with a tidal volume (Vt) of 15 mL/kg predicted body weight (PBW)/positive end-expiratory pressure (PEEP) of 3 cm H(2)O; group L-Vt/3 with a Vt of 6 mL/kg PBW/PEEP of 3 cm H2O; and group L-Vt/10 with a Vt of 6 mL/kg PBW/PEEP of 10 cm H(2)O, for 8 hours. Each group had 6 subjects (n = 6). Prelung and postlung sera were analyzed for inflammatory markers. Hemodynamics, airway mechanics, and arterial blood gases were monitored.ResultsThere were no significant differences in systemic cytokines among groups. There were similar trends of serum inflammatory markers in all subjects. This is in contrast to findings previously published demonstrating increases in inflammatory mediators in bronchoalveolar lavage.ConclusionSystemic inflammatory markers did not correlate with lung injury associated with MV.

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