• Behav. Brain Res. · Nov 2012

    Age-related changes in brain metabolites and cognitive function in APP/PS1 transgenic mice.

    • Shuang-qing Chen, Qing Cai, Yu-ying Shen, Pei-jun Wang, Gao-jun Teng, Wei Zhang, and Feng-chao Zang.
    • Department of Radiology, Suzhou Hospital, Nanjing Medical University, Suzhou 215001, China. sznaonao@163.com
    • Behav. Brain Res. 2012 Nov 1;235(1):1-6.

    AbstractProton magnetic resonance spectroscopy ((1)H-MRS) and the Morris water maze (MWM) have played an important role in Alzheimer's disease (AD) research. The aim of this study was to determine whether (1)H-MRS and the MWM can detect for early AD in APP/PS1 transgenic (tg) mice. (1)H-MRS was performed in 20 tg mice and 15 wild-type mice at 3, 5 and 8 months of age. The concentration of N-acetylaspartate (NAA), glutamate (Glu), myo-inositol (mI), choline (Cho) and creatine (Cr) in the hippocampus were measured, and the NAA/Cr, Glu/Cr, mI/Cr and Cho/Cr ratios were quantified. Additionally, the spatial learning and memory of the mice were evaluated by MWM. The (1)H-MRS revealed that mI levels in tg mice were significantly higher at 3 months of age compared to wt mice, while the NAA and Glu levels in 5- and 8-month-old tg mice were significantly decreased (p<0.05). Additionally, significant cognitive changes only occurred at 8 months of age in APP/PS1 tg mice. These results indicated that metabolic changes preceded overt cognitive dysfunctions in early-stage AD, suggesting that (1)H-MRS is a more sensitive biomarker for assessing early AD.Copyright © 2012 Elsevier B.V. All rights reserved.

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