• Transplant. Proc. · Jul 2013

    Long-term outcome of lung transplantation in previous intravenous drug users with talc lung granulomatosis.

    • J G Weinkauf, L Puttagunta, R Nador, K Jackson, K LaBranche, A Kapasi, J Mullen, D L Modry, K C Stewart, M Thakrar, K Doucette, and D C Lien.
    • Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. justin.weinkauf@ualberta.ca
    • Transplant. Proc. 2013 Jul 1;45(6):2375-7.

    AbstractTalc lung granulomatosis results from the intravenous use of medication intended for oral use. Talc (magnesium silicate) acts as filler in some oral medications; when injected intravenously, it deposits in the lungs leading to airflow obstruction and impaired gas exchange. Allocation of donor lungs to previous intravenous drug users is controversial. After a careful selection process, 19 patients with talc lung granulomatosis have received lung allografts in our program. Long-term survival for these patients is excellent and our results suggest the previous use of intravenous drugs should not necessarily preclude lung transplantation.Copyright © 2013 Elsevier Inc. All rights reserved.

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