• Early human development · Feb 2011

    Comparative Study

    Effects of selective head cooling on cerebral blood flow and metabolism in newborn piglets after hypoxia-ischemia.

    • Guoqiang Cheng, Jinqiao Sun, Laishuan Wang, Xiaomei Shao, and Wenhao Zhou.
    • Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China. gqchengcm@yahoo.com.cn
    • Early Hum. Dev. 2011 Feb 1;87(2):109-14.

    Aimthe effect of selective head cooling on cerebral blood flow (CBF) and cerebral metabolism rate (CMR) was investigated in newborn piglets.Methodsseven days old newborn piglets were randomly assigned to one of the following three groups: Selective head cooling in normal piglets (n=4), selective head cooling after HI (n=6) and normal temperature after HI (n=6). CBF was measured with color microspheres. Cerebral oxygenation metabolism rate (CMRO(2)), Cerebral glucose consumption (CMR(Glu)) and Cerebral lactate production (CMR(lac)) were calculated.Resultin normal piglets, CBF, CMRO(2) and CMR(glu) were significantly decreased at both 35°C (P<0.05) and 32°C (P<0.01), while CMR(lac) did not change. Compared to baseline, CBF and CMRO(2) were significantly reduced (P<0.05), while CMR(glu) and CMR(lac) were significantly increased (P<0.01), AVDO(2) was decreased (P<0.05), while AVD(glu) and AVD(lac) were significantly increased (P<0.01 respectively) in HI piglets with normal temperature respectively. Compared to normal temperature after HI, selective head cooling after HI significantly reduced CMR(glu) and CMR(lac), and AVDO(2), AVD(glu), AVD(lac) were improved at 35°C.Conclusionselective head cooling not only reduced energy consumption, but also improve brain oxygen metabolism in newborn after HI.2010 Elsevier Ltd. All rights reserved.

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