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- Nicholas N Kopjas, Ryan T Jones, Brent Bany, and Peter R Patrylo.
- Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
- Epilepsy Res. 2006 Apr 1;69(1):87-91.
AbstractReeler mice are a model of cortical malformation with enhanced seizure susceptibility. Data suggest that the propensity to anesthesia-induced seizures may be enhanced in animal models with developmental anomalies. Consequently, reeler mice were monitored behaviorally before, during and after isoflurane anesthesia. During recovery, 12% of reeler homozygotes had class I/II seizures while the remaining 88% exhibited convulsive seizures entailing opisthotonus and forepaw drumming. Similar behavior was not observed in controls. These data reveal that reeler mice display isoflurane-induced seizures and provide support for the hypothesis that developmental anomalies may predispose the central nervous system to anesthesia-induced seizures.
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