• Neurosurg Focus · Oct 2008

    Review

    Beta blockers exposure and traumatic brain injury: a literature review.

    • Timothy Y Tran, Irie E Dunne, and John W German.
    • Department of Surgery, Division of Neurosurgery, Albany Medical College, Albany, New York 12108, USA.
    • Neurosurg Focus. 2008 Oct 1;25(4):E8.

    AbstractTraumatic brain injury (TBI) continues to carry a significant public health burden and is anticipated to worsen worldwide over the next century. Recently the authors of several articles have suggested that exposure to beta blockers may improve mortality rates following TBI. The exact mechanism through which beta blockers mediate this effect is unknown. In this paper, the authors review the literature regarding the safety of beta blockers in patients with TBI. The findings of several recent retrospective cohort studies are examined and implications for future investigation are discussed. Future questions to be addressed include: the specific indications for the use of beta blockers in patients with TBI, the optimal type and dose of beta blocker given, the end point of beta blocker therapy, and the safety of beta blockers in cases of severe TBIs.

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