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Ugeskrift for laeger · May 2010
[Actively induced hypothermia following severe traumatic brain injury].
- Per-Olof Grände, Karen-Lise Welling, Vagn Eskesen, and Bertil Romner.
- Universitetssygehuset i Lund, Anaestesi- og Intensivafdelingen, Denmark.
- Ugeskr. Laeg. 2010 May 10;172(19):1437-40.
AbstractA Cochrane metaanalysis and a study performed on children have recently confirmed that therapeutic hypothermia does not improve outcome after severe traumatic brain injury (TBI). TBI is not comparable to a short episode of global ischemia, where therapeutic hypothermia has been shown to improve outcome. The difference may be explained by the fact that hypothermia-induced stress after a traumatic brain injury reduces cerebral perfusion in the penumbra zone, where local circulation is already reduced. Thus, to date there is no indication for therapeutic hypothermia in TBI patients.
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