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- Fabiano Timbó Barbosa.
- Unidade de Emergência Dr. Armando Lages.
- Rev Bras Anestesiol. 2007 Oct 1;57(5):539-42.
Background And ObjectivesPropofol infusion syndrome has been described as a rare, and frequently fatal, syndrome that occurs after prolonged infusion of this drug. It might result in severe metabolic acidosis, rhabdomyolysis, cardiovascular failure, and death. The objective of this report was to review the literature to present aspects related to the propofol infusion syndrome.ContentsThe physiopathology, clinical characteristics, and treatment, of the propofol infusion syndrome as well as dose recommendations for severely ill patients are presented here.ConclusionsPropofol should be used with caution when it is administered as continuous infusion for prolonged periods of time. The development of signs suggestive of the propofol infusion syndrome indicates the drug should be discontinued immediately and support measures instituted.
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