• Serge Duperret, Franck Lhuillier, Vincent Piriou, Emmanuel Vivier, Olivier Metton, Patricia Branche, Guy Annat, Karim Bendjelid, and Jean Paul Viale.
• Department of Anaesthesiology and Intensive Care, Hôpital de la Croix-Rousse, Grande rue de la Croix Rousse, 69317, Lyon, France. serge.duperret@chu-lyon.fr
• Intensive Care Med. 2007 Jan 1;33(1):163-71.

ObjectiveTo evaluate the effect of increased intra-abdominal pressure (IAP) on the systolic and pulse pressure variations induced by positive pressure ventilation in a porcine model.Design And SettingExperimental study in a research laboratory.SubjectsSeven mechanically ventilated and instrumented pigs prone to normovolaemia and hypovolaemia by blood withdrawal.InterventionAbdominal banding gradually increased IAP in 5-mmHg steps up to 30 mmHg.Measurements And Main ResultsVariations in systolic pressure, pulse pressure, inferior vena cava flow, and pleural and transmural (LVEDPtm) left-ventricular end-diastolic pressure were recorded at each step. Systolic pressure variations were 6.1+/-3.1%, 8.5+/-3.6% and 16.0+/-5.0% at 0, 10, and 30 mmHg IAP in normovolaemic animals (mean+/-SD; p<0.01 for IAP effect). They were 12.7+/-4.6%, 13.4+/-6.7%, and 23.4+/-6.3% in hypovolaemic animals (p<0.01 vs normovolaemic group) for the same IAP. Fluctuations of the inferior vena cava flow disappeared as the IAP increased. Breath cycle did not induce any variations of LVEDPtm for 0 and 30 mmHg IAP.ConclusionsIn this model, the systolic pressure and pulse pressure variations, and inferior vena cava flow fluctuations were dependent on IAP values which caused changes in pleural pressure swing, and this dependency was more marked during hypovolaemia. The present study suggests that dynamic indices are not exclusively related to volaemia in the presence of increased IAP. However, their fluid responsiveness predictive value could not be ascertained as no fluid challenge was performed.

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