• Guniz Meyanci Koksal, Cem Sayilgan, Oznur Sen, and Huseyin Oz.
• Department of Anaesthesiology and Reanimation, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. gunizkoksal@hotmail.com
• Crit Care. 2004 Feb 1;8(1):R31-4.

IntroductionThe aim of the present study was to investigate the effects of the stress response on plasma insulin, cortisol, glucose, and urinary vanilmandelic acid during weaning and after extubation, using pressure support (PS), continuous positive airway pressure (CPAP) and T-piece modes.MethodsSixty patients were randomly divided into three groups (n = 20). The PS group received FiO2 ResultsPlasma insulin was greater in group T than in the PS and CPAP groups (P < 0.01 and P < 0.01). The plasma cortisol concentration was greater in group T than in group PS during weaning (P < 0.05) and after extubation (P < 0.05). Blood glucose concentrations were greater in group T than in the other groups (both P < 0.01) both during weaning and post extubation. Urine vanilmandelic acid was greater in group T than in the other groups during weaning and after extubation (both P < 0.001).ConclusionWeaning via the T-piece caused a greater stress response than the PS and CPAP modes.

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