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- V L Webster, D M Cara, R M Walker, M M Ramsay, and A R Aitkenhead.
- University Department of Anaesthesia, Queen's Medical Centre, University Hospital, Nottingham, UK.
- Lab. Anim. 2005 Jan 1;39(1):94-9.
AbstractGeneral anaesthesia in 12 pregnant ewes undergoing surgery for fetal physiological research was supplemented with an intravenous infusion of remifentanil. This allowed us to employ a lighter plane of surgical anaesthesia and to use intermittent positive pressure ventilation. Our aim was to improve fetomaternal outcome. We monitored maternal pulse, blood pressure, transcutaneous oxygen saturation and end-tidal carbon dioxide levels. Remifentanil doses of 0.75-2.0 microg/kg/min were needed and typically this allowed halothane concentrations of 1-1.5% to be used for maintenance of anaesthesia. Surgery lasted up to 2.5 h. All 12 ewes and their singleton fetuses survived the peri- and postoperative period in good condition.
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