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Curr. Opin. Biotechnol. · Dec 1993
ReviewTargets for sepsis therapies: tumor necrosis factor versus interleukin-1.
- D A Russell and R C Thompson.
- Synergen Inc, Boulder.
- Curr. Opin. Biotechnol. 1993 Dec 1;4(6):714-21.
AbstractClinical testing of therapies for sepsis that target tumor necrosis factor and interleukin-1 is currently in progress. It is now clear from early clinical results that patients display a heterogeneous response to anti-cytokine therapies that may be related to the stage or severity of disease. Experimental results show that either cytokine may contribute to the metabolic derangements that lead to organ dysfunction in severe sepsis. They also provide a physiological basis for understanding the benefits of anti-cytokine therapy in the most severely ill patients.
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