• David I Dismukes, Elizabeth J Thomovsky, F A Mann, and John R Middleton.
• Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
• J. Am. Vet. Med. Assoc. 2010 Feb 1;236(3):309-11.

ObjectiveTo determine the magnitude of the change in colloid oncotic pressure (COP) associated with general anesthesia in dogs undergoing a variety of elective procedures.DesignCohort study.Animals50 client-owned dogs.ProceduresFor each dog, preanesthetic and postanesthetic PCV, plasma total solids (TS) concentration, and COP were determined. The procedures requiring anesthesia, volume of crystalloid fluids administered IV, duration of anesthesia, age, weight, and sex were recorded.ResultsPostanesthetic PCV (mean +/- SD, 41.8 +/- 5.4%), TS concentration (6.3 +/- 0.8 g/dL), and COP (19.4 +/- 3.6 mm Hg) were significantly decreased, compared with preanesthetic values (48.8 +/- 5.9%, 7.2 +/- 0.7 g/dL, and 24.4 +/- 4.2 mm Hg, respectively). None of the variables tested could be used to reliably predict changes in COP.Conclusions And Clinical RelevanceResults suggested that COP in healthy dogs may decrease by 5 mm Hg on average after general anesthesia and that this decrease may not be reliably predicted by the volume of fluids administered IV during anesthesia or by the concurrent measured decrease in TS concentration.

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