• Curr Pain Headache Rep · Jun 2006

    Review

    Duloxetine for neuropathic pain based on recent clinical trials.

    • David Fishbain, Kim Berman, and Daniel K Kajdasz.
    • Department of Psychiatry, Miller School of Medicine, University of Miami, 1400 N.W. 10th Avenue, Suite 301, Miami Beach, FL 33136, USA. d.fishbain@miami.edu
    • Curr Pain Headache Rep. 2006 Jun 1; 10 (3): 199-204.

    AbstractThe treatment of neuropathic pain with antidepressants has a long history. Early studies were contradictory and were limited by small numbers of patients. When evaluated meta-analytically, these studies indicated that antidepressants do have efficacy for neuropathic pain. However, none of the antidepressants used in these studies have gained approval by the US Food and Drug Administration (FDA) for this indication, and were generally associated with a high side-effect burden. Recently, duloxetine, a dual-action reuptake inhibitor, has demonstrated significant efficacy in the management of diabetic peripheral neuropathic pain in three double-blind, placebo-controlled trials and was approved by the FDA for this indication. These studies are discussed in this article.

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