• J L Robotham, R C Bell, F R Badke, and M K Kindred.
• Crit. Care Med. 1985 Aug 1;13(8):617-24.

AbstractWe evaluated changes in left ventricular (LV) geometry in ten dogs during intermittent positive-pressure ventilation (IPPV) with and without 10 cm H2O of positive end-expiratory pressure (PEEP). The dimensions during expiration and inspiration decreased in all three orthogonal axes during PEEP, consistent with decreased LV end-diastolic (ED) and end-systolic (ES) volumes. Within a respiratory cycle, the anterior-posterior (AP) ED dimension during inspiration increased with IPPV alone but decreased when PEEP was added, consistent with presumed differences in pulmonary venous return. This caused opposite changes in AP percent regional shortening. Septal-lateral free wall (SL) percent regional shortening decreased during inspiration with both IPPV and PEEP, but the respiratory variation was significantly less during PEEP. Thus, PEEP did not simply produce a smaller version of the same events seen during IPPV alone. The larger decreases with PEEP observed in ED compared to ES dimensions in the AP and SL axes suggest a dominant regional preload effect, whereas the larger fall in the long axis ES compared to ED dimension suggests a primary regional decrease in afterload. Measurements of the right ventricular SL axis in three dogs showed an overall reduction with PEEP, with the inspiratory dimensions being minimal during both IPPV alone and with PEEP. Thus, ventricular interdependence cannot account for the diminished LV SL dimension with PEEP during any part of the respiratory cycle. These findings suggest that the motion of the LV free wall influenced by changes in lung volume may be at least as important as septal motion in determining LV geometry with PEEP.(ABSTRACT TRUNCATED AT 250 WORDS)

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