• Br J Anaesth · Dec 1995

    Case Reports

    Ventilatory arrest after a fluid challenge in a neonate receiving s.c. morphine.

    • A R Wolf, R A Lawson, and S Fisher.
    • Department of Anaesthesia, Royal Hospital for Sick Children, Glasgow.
    • Br J Anaesth. 1995 Dec 1;75(6):787-9.

    AbstractS.c. infusions of morphine have been advocated for postoperative analgesia in children, but experience with this technique is limited. We report a case in which an s.c. infusion of morphine given after operation to a neonate failed to provide acceptable analgesia until the child had been adequately rehydrated. However, restoration of peripheral perfusion with a fluid challenge was followed by sudden ventilatory arrest which required resuscitation and naloxone infusion. This report emphasizes the dangers of giving morphine by a peripheral route in the dehydrated or hypovolaemic infant.

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