• Biomarkers · Jun 2013

    Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction.

    • Johan Mårtensson, Max Bell, Shengyuan Xu, Matteo Bottai, Bo Ravn, Per Venge, and Claes-Roland Martling.
    • Section of Anaesthesia and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. johan.martensson@karolinska.se
    • Biomarkers. 2013 Jun 1;18(4):349-56.

    ObjectiveNeutrophil gelatinase-associated lipocalin (NGAL) is secreted by injured kidney cells as well as by activated neutrophils in response to bacterial infections. We assessed the influence of acute renal dysfunction on the association between plasma NGAL and sepsis.MethodsNGAL was measured daily in 138 critically ill patients. Simultaneous recordings of sepsis status and fluctuations in renal function were made.ResultsElevated NGAL was associated with sepsis independent of level of acute renal dysfunction. A cut-off value of 98 ng/mL distinguished sepsis from systemic inflammation with high sensitivity (0.77) and specificity (0.79).ConclusionsPlasma NGAL can help clinicians to identify bacterial infections in critically ill patients.

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