• Hiroyuki Jimbo, Shinetsu Kamata, Kouki Miura, Shunji Asamoto, Shinichiro Tada, Takahiro Endo, Tatsuo Masubuchi, Narihiro Nakamura, and Chihiro Fushimi.
• Skull Base Center, International University of Health and Welfare, Mita Hospital, Tokyo, Japan. hjimbo@tokyo-med.ac.jp
• Neurol. Med. Chir. (Tokyo). 2010 Jan 1;50(1):20-6; discussion 26.

AbstractCancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years. En bloc resections using anterior skull base resection, orbital resection, middle fossa resection, and combined procedures of these three resections were performed. Using a combination of adjuvant radiation and chemotherapy, we have achieved a 2-year disease-free survival rate of 90% in these cases. However, potential complications include cerebrospinal fluid leakage, meningitis, abscess formation, pneumocephalus, frontal brain contusion, trismus, and dysphagia as a functional complication. We believe that the optimal management of such malignant tumors involves a multimodal and multidisciplinary team approach. Here we present our recent institutional experience and treatment policy employed during the past 3 years.

61 keywords...

hide…