• Heart · Oct 2014

    Comparative Study

    High-sensitivity versus conventional troponin for management and prognosis assessment of patients with acute chest pain.

    • Juan Sanchis, Sergio García-Blas, Luis Mainar, Anna Mollar, Lidia Abellán, Silvia Ventura, Clara Bonanad, Luciano Consuegra-Sánchez, Mercé Roqué, Francisco J Chorro, Eduardo Núñez, and Julio Núñez.
    • Cardiology Department, Medicine Department, University Clinic Hospital, INCLIVA, València University, Valencia, Spain.
    • Heart. 2014 Oct 1;100(20):1591-6.

    ObjectivesHigh-sensitivity troponin (hs-cTn) is substituting conventional cTn for evaluation of chest pain. Our aim was to assess the impact on patient management and outcome.MethodsA total of 1372 consecutive patients presenting at the emergency department with non-ST-elevation acute chest pain were divided into two periods according to the cTn assay used, conventional (n=699, March 2008 to July 2010) or hs-cTn (n=673, November 2010 to March 2013). Management policies were similar and according to guidelines. The primary endpoint was major adverse cardiac events (MACE) at 6 months (death, myocardial infarction, readmission by unstable angina or postdischarge revascularisation).ResultsThere were minor differences in baseline characteristics. In the hs-cTn period, more patients elevated cTn (73% vs 37%, p=0.0001) leading to more coronary angiograms (77% vs 55%, p=0.0001) and revascularisations (45% vs 31%, p=0.0001); conversely, fewer patients were initially assigned to exercise testing (14% vs 36%, p=0.0001) and, therefore, discharged early after a negative result (7% vs 22%, p=0.0001). At 6 months, 135 patients suffered MACE, including 54 deaths. After adjusting for a Propensity Score, hs-cTn use was not significantly associated with MACE (HR=0.99; 95% CI 0.70 to 1.41; p=0.98) or mortality (HR=1.02; 95% CI 0.59 to 1.77; p=0.95), though the risk of longer hospitalisation stay increased at the index episode (OR=1.35, 95% CI 1.07 to 1.71, p=0.02).Conclusionshs-cTn simplified chest pain triage on avoiding a more complex evaluation with non-invasive tests in the chest pain unit, but prompted longer hospitalisations and more invasive procedures without impacting on the 6-month outcomes.

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