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Case Reports
Use of alpha-agonists for management of anaphylaxis occurring under anaesthesia: case studies and review.
- M Heytman and A Rainbird.
- Department of Anaesthesia, The Townsville Hospital, Douglas, QLD 4814, Australia.
- Anaesthesia. 2004 Dec 1;59(12):1210-5.
AbstractAnaphylaxis is an uncommon but serious complication of anaesthesia. Most current guidelines for the management of anaphylaxis list only epinephrine as a vasopressor to use in the event of cardiovascular collapse. We present two cases of anaphylaxis under anaesthesia where return of spontaneous circulation was refractory to epinephrine, but occurred following the administration of the alpha-agonist metaraminol. Potential advantages and disadvantages of using epinephrine in this setting, the role of alpha-agonists and some potential mechanisms accounting for their role in successful management are reviewed.
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