• Am J Perinatol · Nov 1996

    Evaluation of hypothalamic-pituitary-adrenal axis in premature infants treated with dexamethasone.

    • A L Alkalay, A H Klein, R A Nagel, and J J Pomerance.
    • Division of Neonatology, Ahmanson Pediatric Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
    • Am J Perinatol. 1996 Nov 1;13(8):473-7.

    AbstractResults of a national survey of the current use of steroids in newborns in 1993 showed that 95% of the neonatologists in the United States have used dexamethasone for neonates at risk for chronic lung disease. Dexamethasone therapy for a period of a week or longer is associated with suppression of the hypothalamic-pituitary-adrenal axis (HPAA) in a substantial number of premature infants. A review of our current understanding of the biochemical tests evaluating HPAA function in premature infants and suggested guidelines for HPAA evaluation and management following dexamethasone therapy are presented.

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