• J. Cardiothorac. Vasc. Anesth. · Apr 2005

    Normobaric hyperoxia reduces cardiac index in patients after coronary artery bypass surgery.

    • Johann M Harten, Keith J Anderson, John Kinsella, and Michael J Higgins.
    • Department of Anaesthesia, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom. jharten@doctors.org.uk
    • J. Cardiothorac. Vasc. Anesth. 2005 Apr 1; 19 (2): 173-5.

    ObjectiveThe purpose of this study was to assess the hemodynamic changes in response to normobaric hyperoxia in patients immediately after coronary artery bypass surgery.DesignObservational study.SettingSingle-center university hospital.ParticipantsPatients immediately after coronary artery bypass surgery.InterventionChange of fractional inspired oxygen concentration from baseline (< or =0.60) to 1.0 and return to baseline.Measurements And Main ResultsCardiovascular changes were assessed with a lithium dilution technique. Cardiac index decreased from 2.82 to 2.52 L/min/m2 (10.6%). Heart rate decreased from 85.9 to 82.5 beats/min (4.0%), and the systemic vascular resistance index increased from 1,858 to 2,304 dyne/s/cm5/m2 (24.1%). Stroke index or mean arterial pressure did not change significantly. On reducing the FIO2 from 1.0 to the baseline FIO2 , there was significant reversal of the previous changes in heart rate and systemic vascular resistance. Heart rate increased from 82.5 to 84.0 beats/min (1.8%), and the systemic vascular index decreased from 2304 to 1932 dyne/s/cm5/m2 (16.1%). The cardiac output did not return to baseline, and the mean arterial pressure decreased from 69.6 to 64.4 mmHg (7.6%).ConclusionsExposing patients after coronary artery surgery to hyperoxia induces significant hemodynamic changes.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        

    hide…