• Ann. Thorac. Surg. · Feb 1995

    Randomized Controlled Trial Comparative Study Clinical Trial

    Hemostatic efficacy of dipyridamole, tranexamic acid, and aprotinin in coronary bypass grafting.

    • R G Speekenbrink, A B Vonk, C R Wildevuur, and L Eijsman.
    • Department of Thoracic Surgery, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
    • Ann. Thorac. Surg. 1995 Feb 1;59(2):438-42.

    AbstractSixty patients (four groups of 15 patients) were entered in a randomized, controlled study to compare the efficacy of prophylactic treatment with dipyridamole, tranexamic acid, and aprotinin to reduce bleeding after elective coronary artery bypass grafting. Only patients with a preoperative platelet count of less than 246 x 10(9)/L were selected because a previous study showed that these individuals are at risk for increased postoperative bleeding. Compared to control subjects, postoperative blood loss 6 hours after operation was significantly reduced by tranexamic acid (674 +/- 411 versus 352 +/- 150 mL; p < 0.05) and by aprotinin (270 +/- 174 mL; p < 0.01). Dipyridamole did not reduce postoperative blood loss and was associated with complications in 3 patients. We conclude that hemostasis after cardiac operations can be improved with tranexamic acid and aprotinin. Dipyridamole appeared to be ineffective.

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