• G M Hadjigeorgiou, K Paterakis, E Dardiotis, M Dardioti, K Aggelakis, A Tasiou, G Xiromerisiou, A Komnos, E Zintzaras, N Scarmeas, A Papadimitriou, and A Karantanas.
• Department of Neurology, University Hospital of Larissa, Medical School, University of Thessaly, Larissa 41222, Greece. gmhadji@med.uth.gr
• Neurology. 2005 Oct 11;65(7):1077-82.

ObjectiveTo investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI).MethodsData from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant.ResultsCompared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI (adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant.ConclusionThere is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.

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