• Jacqueline J Kraus, Michael D Metzler, and William M Coplin.
• Department of Neurology, Wayne State University, Detroit, MI 48201, USA.
• Neurol. Res. 2002 Jan 1;24 Suppl 1:S47-57.

AbstractThe outcomes of devastating neurological emergencies such as stroke and subarachnoid hemorrhage may be measurably improved by timely treatment in a neurointensive care unit (NICU). Optimal care requires a multidisciplinary approach, with attention to a wide range of treatment issues. This review examines the key therapeutic concerns in the NICU management of acute ischemic and hemorrhagic stroke and subarachnoid hemorrhage, including mechanical ventilation, blood pressure management, cardiac monitoring, intracranial pressure assessment, vasospasm, seizures, sedation, fluids, electrolytes, and nutrition. The discussion of mechanical ventilation includes rapid sequence induction and intubation, indication for intubation and extubation, and prognostic factors in mechanical ventilation. Differing blood pressure management concerns in hemorrhagic and ischemic events are discussed, and specific target blood pressures and pharmacologic interventions are reviewed. The discussion of cardiac monitoring includes concurrent stroke and cardiac ischemia and arrhythmias, cardiac imaging, anticoagulation, and vasopressor therapy. The importance, monitoring and management of cerebral blood flow and intracranial pressure (ICP) are discussed, and strategies for treatment of elevated ICP are outlined in detail. The discussion of vasospasm includes evaluation, prophylaxis, and treatment with medications, hypervolemic hemodilution, and angioplasty. Management of seizure and status epilepticus in stroke and subarachnoid hemorrhage are reviewed and current algorithms are presented. The management of fluids, electrolytes and enteral nutrition are also reviewed.

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