• Curr Protoc Neurosci · Oct 2007

    Models of nociception: hot-plate, tail-flick, and formalin tests in rodents.

    • Anthony W Bannon and Annika B Malmberg.
    • Icagen Inc., Durham, North Carolina, USA.
    • Curr Protoc Neurosci. 2007 Oct 1;Chapter 8:Unit 8.9.

    AbstractExperimental models of pain include tests of response thesholds to high intensity stimuli (acute pain tests) and changes in spontaneous or evoked behavioral responses in animals with peripheral injury or inflammation (persistent pain models). Acute thermal pain is modeled by the hot-plate and tail-flick test, while persistent pain can be modeled by the formalin test. This unit presents protocols for all three of these tests, including preparation of animals (rats or mice), administration of a compound being tested for its analgesic properties and data collection.Copyright 2007 by John Wiley & Sons, Inc.

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