• Pinar Zeyneloglu, Asli Donmez, Banu Bilezikci, and Sukru Mercan.
• Department of Anesthesiology, Baskent University Faculty of Medicine, Ankara, Turkry. pinar_bz@hotmail.com
• J. Cardiothorac. Vasc. Anesth. 2005 Jun 1; 19 (3): 329-33.

ObjectiveCorrective surgery for congenital heart defects in children frequently requires cardiopulmonary bypass (CPB). Serum and bronchoalveolar levels of interleukin-6 (IL-6) may be useful in assessing the severity of the systemic inflammatory response after CPB. In the present study, the authors aimed to compare the effects of ketamine anesthesia and isoflurane anesthesia with respect to serum and tracheobronchial aspirate (TBA) IL-6 levels in infants undergoing CPB for cardiac surgery.DesignProspective and randomized controlled study.SettingUniversity-based teaching hospital.ParticipantsThirty-four infants aged 2 to 24 months were randomized into 2 groups.InterventionsIn group K (n = 17), anesthesia was induced with intravenous (IV) ketamine, 1 to 2 mg/kg, and fentanyl, 1 to 2 microg/kg, and was maintained with infusions of ketamine, 25 to 75 microg/kg/min, and fentanyl, 10 microg/kg/h. In group I (n = 17), induction was achieved with IV thiopental sodium, 3 to 5 mg/kg, and fentanyl, 1 to 2 microg/kg, and was maintained with 1% isoflurane and fentanyl, 10 mug/kg/h. Blood and TBA samples were obtained at 6 and 4 stages, respectively.Measurements And Main ResultsSerum IL-6 and TBA IL-6 levels were similar in the 2 groups at all stages (p > 0.05).ConclusionThe present results show that ketamine anesthesia does not provide superiority over isoflurane anesthesia with respect to serum and TBA IL-6 levels.

43 keywords...

hide…