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J. Pediatr. Hematol. Oncol. · May 2004
Case ReportsSuccessful treatment of refractory autoimmune hemolytic anemia with monthly rituximab following nonmyeloablative stem cell transplantation for sickle cell disease.
- Ashok Raj, Salvatore Bertolone, and Alexandra Cheerva.
- Department of Pediatrics, Division of Pediatric Hematology/Oncology, School of Medicine, University of Louisville, Louisville, Kentucky 40202, USA.
- J. Pediatr. Hematol. Oncol. 2004 May 1;26(5):312-4.
AbstractAutoimmune hemolytic anemia (AIHA) can occur following hematopoietic stem cell transplantation (HSCT) and may be associated with other cytopenias. It can also occur in the context of chronic red cell transfusion in patients maintained on hypertransfusion regimens. There are an increasing number of reports on the successful treatment of autoimmune cytopenias with the monoclonal anti-CD20 antibody rituximab, including a few patients in a post-HSCT setting. The authors report the successful treatment with rituximab of refractory AIHA following allogeneic nonmyeloablative bone marrow transplantation in a child with sickle cell disease.
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