• C A Sullivan, C A Johnson, H Roach, R W Martin, D K Stewart, and J C Morrison.
• Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
• Am. J. Obstet. Gynecol. 1996 May 1;174(5):1565-8.

ObjectiveWe attempted to determine whether the antiemetic ondansetron would be more effective than promethazine in treating hyperemesis gravidarum.Study DesignPatients with hyperemesis gravidarum who required hospital admission were randomized to receive either intravenous ondansetron (n = 15) or intravenous promethazine (n = 15) in a double-blind manner. Severity of disease was determined by electrolyte status, weight loss, ketonuria, and prior use of outpatient antiemetics. Outcome variables included degree of nausea, weight gain during treatment, days of hospitalization, and number of medication doses.ResultsIn this preliminary investigation ondansetron offered no advantage when compared with promethazine in the relief of nausea, weight gain, days of hospitalization (4.5 +/- 2.3 vs 4.5 +/- 1.5), and total doses of medication per hospitalization (2.1 +/- 1.2 vs 1.9 +/- 1.3).ConclusionThis preliminary trial of ondansetron demonstrated no benefit over promethazine in patients hospitalized for hyperemesis gravidarum.

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