• D Mihu, N Costin, Carmen Mihaela Mihu, Ligia Daniela Blaga, and Raluca Bogdana Pop.
• Dominic Stanca Clinic of Obstetrics and Gynecology, School of Medicine, Haţieganu University of Medecine and Pharmacy Cluj-Napoca.
• Rev Med Chir Soc Med Nat Iasi. 2008 Oct 1;112(4):1019-25.

AimDetermination by a high sensitivity technique of serum C-reactive protein (CRP), a sensitive marker of inflammation in women with preeclampsia compared to normal pregnancy and investigation of the relationship between CRP and the severity of the preeclamptic syndrome.Material And MethodThe study included 40 women with preeclampsia and 40 control subjects with normal pregnancies in the last trimester of pregnancy. The serum CRP concentration was determined using the universal high sensitivity immunoturbidimetric assay.ResultsThe serum CRP concentration was significantly higher (p < 0.001) in preclampsia (5.69 +/- 1.8 mg/L) compared to normal pregnancy (2.89 +/- 1.2 mg/L). In women with preeclampsia, CRP correlated positively and significantly with diastolic blood pressure, proteinuria and uric acid levels. Maternal CRP values also correlated negatively and significantly with fetal weight at birth.ConclusionsOur results demonstrate that serum CRP is increased in preeclampsia and represents a marker of the severity of the preeclamptic syndrome and of fetal weight at birth. Taking into consideration these observations and the fact that CRP testing is rapid and relatively inexpensive, we recommend the use of this acute phase reagent in clinical practice, in all women with preeclampsia in order to establish the prognosis of the disease.

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