• J. Cardiothorac. Vasc. Anesth. · Aug 2003

    Randomized Controlled Trial Comparative Study Clinical Trial

    Fenoldopam for renal protection in patients undergoing cardiopulmonary bypass.

    • Philippe-Primo Caimmi, Lorenzo Pagani, Ezio Micalizzi, Cosimo Fiume, Simona Guani, Massimo Bernardi, Fillipo Parodi, Gualtiero Cordero, Maura Fregonara, Emmanouil Kapetanakis, Massinniano Panella, and Carlo Degasperis.
    • Department of Cardiac Surgery, University of East Piedmont, School of Medicine, Novara, Italy. philippeprimo.caimmi@tin.it
    • J. Cardiothorac. Vasc. Anesth. 2003 Aug 1;17(4):491-4.

    ObjectiveTo evaluate the possible protective effects of fenoldopam on renal function in patients undergoing cardiopulmonary bypass.DesignProspective, randomized trial.SettingUniversity teaching hospital.ParticipantsOne hundred sixty consecutive patients with serum creatinine >1.5 mg/dL who underwent uncomplicated moderate hypothermic cardiopulmonary bypass for cardiac surgery.InterventionsA random group of 80 patients was managed conventionally (group A), whereas another random group of 80 patients received continuous intravenous administration of low-dose fenoldopam (0.1-0.3 microg/kg/min) during cardiopulmonary bypass and in the early postoperative period (group B).Measurements And Main ResultsAn improvement of postoperative renal parameters were observed only in group B: preoperative serum creatinine 1.82 +/- 0.2 versus 1.43 +/- 0.73 postoperatively (p < 0.001), preoperative creatinine clearance 51.34 +/- 22.26 versus 67.14 +/- 18.55 postoperatively (p < 0.001).ConclusionsIn this study, fenoldopam was an effective agent in the prevention of renal dysfunction after cardiopulmonary bypass.

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