• James J Lewis, Katherine L Fielding, Alison D Grant, Violet N Chihota, Flora Popane, Mariette Luttig, Dorothy Muller, Leonie Coetzee, and Gavin J Churchyard.
• London School of Hygiene and Tropical Medicine, London, United Kingdom ; The Aurum Institute for Health Research, Johannesburg, South Africa.
• Plos One. 2013 Jan 1;8(11):e81376.

SettingThe "Thibela TB" cluster randomised trial of community-wide isoniazid preventive therapy (IPT) to reduce tuberculosis incidence in the South African gold mines.ObjectivesTo determine the proportion of participants eligible for IPT and the reasons and risk factors for ineligibility, to inform the scale-up of IPT.DesignCross-sectional survey of participants in intervention clusters (mine shafts) consenting to tuberculosis screening and assessment for eligibility to start IPT.ResultsAmong 27,126 consenting participants, 94.7% were male, the median age was 41 years, 12.2% reported previous tuberculosis, 0.6% reported ever taking IPT and 2.5% reported currently taking antiretroviral therapy. There were 24,430 (90.1%) assessed as eligible to start IPT, of whom 23,659 started IPT. The most common reasons for ineligibility were having suspected tuberculosis that was subsequently confirmed by a positive smear and/or culture (n=705), excessive alcohol consumption (n=427) and being on tuberculosis treatment at time of initial screen (n=241). Ineligibility was associated with factors including older age, female gender, prior history of tuberculosis and being in "HIV care". However, at least 78% were eligible for IPT in all of these sub-groups.ConclusionsThe vast majority of participants in this community-wide intervention were eligible for IPT.

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