• Di Yi Jun Yi Da Xue Xue Bao · Feb 2002

    Clinical Trial Controlled Clinical Trial

    [Dexamethasone enhances the effect of tropisetron and ondansetron against nausea and vomiting against nausea and vomiting after patient-controlled analgesia].

    • Chen Wang, Ning Xu, Li-Ze Xiong, Hui-Fen Liu, Xiao-Yan Yang, Zhi-Hong Lu, Peng-Tu Sheng, and Li-Yun Wang.
    • Departments of, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China. wangchen@fmmu.edu.cn
    • Di Yi Jun Yi Da Xue Xue Bao. 2002 Feb 1;22(2):159-61.

    ObjectiveTo study the enhancement by dexamethasone of the effect of ondansetron and tropiesetron against postoperative nausea and vomiting (PONV) in patients receiving patient-controlled analgesia (PCA) and observe the effect of dexamethasone on wound healing.MethodsOne hundred and twenty elective surgical patients receiving PCA were divided into 4 groups, including 2 control groups with the prescription of ondansetron (8 mg) and tropiesetron (3 mg) respectively (control A and B) and 2 observation groups in which the patients were given ondansetron (8 mg) plus dexamethasone (10 mg) and tropiesetron (3 mg) plus dexamethasone (10 mg) respectively (observation groups C and D). The incidence and severity of PONV was observed at 4, 8, 2, 24 h and 2, 3 d postoperatively, and the time and grade of healing of the wound evaluated.ResultsSignificant difference in PONV between group A and group B was observed (P<0.01), and in the observation groups, PONV was markedly reduced compared with the control groups (C vs A, P<0.01; D vs B, P<0.05). In light of the time and grade of wound healing, the observation groups differed little from the control groups.ConclusionDexamethasone (10 mg) can greatly enhance the effect of ondansetron and tropiesetron against PONV in patients receiving PCA without interfering the healing of the wound.

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