• Didier Tchetche, Robert M A Van der Boon, Nicolas Dumonteil, Alaide Chieffo, Nicolas M Van Mieghem, Bruno Farah, Gill L Buchanan, Redouane Saady, Bertrand Marcheix, Patrick W Serruys, Antonio Colombo, Didier Carrie, Peter P T De Jaegere, and Jean Fajadet.
• Clinique Pasteur, Toulouse, France. d.tchetche@clinique-pasteur.com
• Am. Heart J. 2012 Sep 1;164(3):402-9.

BackgroundLittle is known about the impact of bleeding and red blood cells transfusion (RBC) on the outcome post transcatheter aortic valve implantation (TAVI).MethodsBetween November 2005 and August 2011, 943 consecutive patients underwent TAVI. Bleeding was assessed according to the Valve Academic Research Consortium definitions. Patients receiving RBC were compared to those not requiring transfusion.ResultsLife-threatening and major bleedings occurred respectively in 13.9% and 20.9% of the patients, significantly more frequently in the RBC cohort. Vascular complications occurred in 23.2% of the patients. Major and minor vascular complications were more frequent in the RBC group: 19.3 vs 5.2%, P < .001; 15.3 vs 9%, P = .003, respectively. Thirty-day all-cause mortality was 7.2%. Of the overall cohort, 38.9% required RBC transfusion; those receiving at least 4 U of RBC had higher 30-day all-cause mortality than those receiving 1 to 4 U of RBC and those not requiring transfusion: 14.4%, vs 6.3% vs 6.3%, respectively, P = .008. By multivariate analysis, transfusion of RBC was associated with an increased 30-day and 1-year mortality. Major stroke and all stages of acute kidney injury were significantly more frequent in the RBC cohort.ConclusionsBleeding is frequent after TAVI, mainly driven by vascular complications. RBC transfusion was associated with increased mortality at 1 year and increased risk of major stroke and acute kidney injury. Specific scores are needed to identify the patients at higher risk for TAVI-related bleeding and RBC transfusion.Copyright © 2012 Mosby, Inc. All rights reserved.

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