• Mark A Ware and Gary J Bennett.
• The Alan Edwards Pain Management Unit, McGill University Health Centre, McGill University, Montreal, Quebec, Canada; Department of Family Medicine, McGill University, Montreal, Quebec, Canada; The Louise and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada. Electronic address: mark.ware@mcgill.ca.
• Pain. 2014 Jul 1;155(7):1412-5.

AbstractWe describe a young woman who had had treatment-refractory complex regional pain syndrome (CRPS) for 6 years before receiving antibiotic treatment with cefadroxil (a cephalosporin derivative) for a minor infection. Cefadroxil reduced the patient's pain and motor dysfunction (dystonia and impaired voluntary movement) within days; the pain and motor disorder returned when cefadroxil was discontinued; and both again abated when cefadroxil was re-instituted. The patient has now had symptom relief for more than 3 years on continuing cefadroxil therapy. We discuss this case in the context of previous reports of antibiotic treatment relieving neuropathic pain in experimental animals.Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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