• Yutaka Harita, Kiyonobu Ishizuka, Atsushi Tanego, Noriko Sugawara, Hiroko Chikamoto, Yuko Akioka, Haruko Tsurumi, Kenichiro Miura, Yoshimitsu Gotoh, Makoto Tsujita, Takayuki Yamamoto, Keiji Horike, Asami Takeda, Akira Oka, Takashi Igarashi, and Motoshi Hattori.
• Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, haritay-ped@h.u-tokyo.ac.jp.
• Pediatr. Nephrol. 2014 Sep 1;29(9):1553-60.

BackgroundCirculating factor(s) has been thought to be the underlying cause of focal segmental glomerulosclerosis (FSGS), and recent studies foster this idea by demonstrating increased soluble urokinase receptor (suPAR) levels in the serum of FSGS patients.MethodsTo explore the possible contribution of suPAR in FSGS pathogenesis, we analyzed serum suPAR levels in 17 patients with FSGS and compared them with those in patients with steroid-sensitive nephrotic syndrome, chronic glomerulonephritis, or non-glomerular kidney diseases.ResultsSerum suPAR levels in patients with FSGS were higher than those in patients with steroid-sensitive nephrotic syndrome or chronic glomerulonephritis, but not higher than those in patients with non-glomerular kidney diseases. suPAR levels negatively correlate with estimated glomerular filtration rate and were decreased after renal transplantation in patients with FSGS as well as in those with non-glomerular kidney diseases. Furthermore, 6 FSGS patients with post-transplant recurrence demonstrated that suPAR levels were not high during the recurrence.ConclusionsBased on our results, elevated suPAR levels in FSGS patients were attributed mainly to decreased glomerular filtration. These data warrant further analysis for involvement of possible circulating factor(s) in FSGS pathogenesis.

15 keywords...

hide…