• Baillieres Clin Obstet Gynaecol · Sep 1992

    Review

    The immune system in health and disease.

    • D J Dudley.
    • Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City 84132.
    • Baillieres Clin Obstet Gynaecol. 1992 Sep 1;6(3):393-416.

    AbstractFor an immune response against an eliciting antigen, innate and adaptive immune mechanisms interact to provide a specific and appropriate response characterized by self-non-self discrimination and memory. This non-random process involves antigen presentation followed by T cell recognition and activation with the elaboration of T cell-derived lymphokines. The nature and amount of lymphokine production from antigen-activated T cells then determines the predominant immune response (e.g. cytotoxicity versus antibody). Exogenous regulatory factors, including steroid hormones, prostaglandins, and cytokines, modulate immune responsiveness. How these regulatory factors influence the immune response during specific host-parasite interactions determines the predominant immune response to specific antigen. As the regulation of the immune response is unravelled, new and powerful immunomodulatory therapies will be developed and utilized to improve the immune response and host survival.

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