• Critical care medicine · Mar 1985

    Case Reports

    Severe combined respiratory and myocardial failure treated with high-frequency ventilation.

    • N S Yeston, R C Grasberger, and J R McCormick.
    • Crit. Care Med. 1985 Mar 1;13(3):208-9.

    AbstractHigh levels of positive end-expiratory pressure (PEEP) impair cardiac output. The subsequent lowering of mixed venous oxygenation, when coupled with a significant intrapulmonary shunt, may dramatically depress PaO2. We present a patient whose severe myocardial and respiratory insufficiency was unmanageable on conventional ventilation with high levels of PEEP and maximal inotropic support. High-frequency ventilation superimposed on conventional ventilation lowered peak airway pressure and dramatically improved both cardiac and pulmonary function.

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