• C Richard Chapman, Gary Donaldson, Jennifer Davis, Donald Ericson, and John Billharz.
• Department of Anesthesiology, School of Medicine, University of Utah, Salt Lake City, Utah, USA. crc20@utah.edu
• Pain Med. 2009 Apr 1;10(3):481-7.

ObjectiveThis exploratory investigation compared patterns of postoperative pain over 6 days in normal patients recovering from surgery with those of patients using opioid medications for chronic pain. It tested the following hypotheses: 1) Chronic pain patients have a different pattern of postoperative pain than normals; 2) Women have a different pattern of postoperative pain resolution than men.PatientsNormal (N = 96) and chronic pain (N = 42) patients undergoing surgery served as subjects.DesignThe study employed a linear mixed effects model to compare repeated measures of pain in the two patient groups.Outcome MeasuresPatients rated pain daily following surgery over 6 days. Each patient's pain pattern is a linear trend having an intercept (initial pain level) and a slope (rate of pain change over days).ResultsThe chronic pain patients initially reported a higher mean pain level, and they differed from normal patients in their average postoperative pain patterns (P < 0.001), as did men and women (P = 0.039). Whereas normals decreased in pain report over the 6 days of recovery at an average rate of -0.35 units per day, chronic pain patients changed at an average rate of only -0.06 units per day (P < 0.001). Women began at day 0 with greater average pain than men (6.15 vs 5.16, P = 0.029) but resolved their pain more rapidly (-0.291 points per day vs -0.118 points per day, P = 0.017).ConclusionsSurgical patients who have chronic pain and use opioid medications for that pain have more postoperative pain than normals and resolve that pain more slowly.

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