• Neurobiology of aging · Apr 2013

    Lack of association between PICALM rs3851179 polymorphism and Alzheimer's disease in Chinese population and APOEε4-negative subgroup.

    • Guiyou Liu, Liangcai Zhang, Rennan Feng, Mingzhi Liao, Yongshuai Jiang, Zugen Chen, Bin Zhao, and Keshen Li.
    • Institute of Neurology, Guangdong Medical College, District of Xiashan, Zhanjiang, Guangdong, China. liuguiyou1981@163.com
    • Neurobiol. Aging. 2013 Apr 1;34(4):1310.e9-10.

    AbstractRecently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOEε4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOEε4-negative subgroup.Copyright © 2013 Elsevier Inc. All rights reserved.

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