• HPB Surg · Jan 1999

    Comparative Study Clinical Trial

    Bilirubin as an anti-oxidant for surgical stress: a preliminary report of bilirubin oxidative metabolites.

    • N Kozaki, S Shimizu, K Chijiiwa, K Yamaguchi, S Kuroki, K Shimoharada, T Yamaguchi, H Nakajima, and M Tanaka.
    • First Department of Surgery, Kyushu University Faculty of Medicine, Fukuoka, Japan.
    • HPB Surg. 1999 Jan 1;11(4):241-8.

    BackgroundBilirubin has been recognized as an anti-oxidant. The purpose of this study was to examine whether bilirubin would act as an antioxidant for surgical stress in humans.Materials And MethodsSerum bilirubin and urinary bilirubin oxidative metabolites (BOM) were measured in 96 patients who underwent surgery. The antioxidant activity of bilirubin was assessed using BOM measured by enzyme-linked immunosorbent assay with an anti-bilirubin monoclonal antibody.ResultsSerum bilirubin levels increased after surgery in all 96 patients (p < 0.01), but did not correlate with operation time or blood loss (p = 0.53 and p = 0.28, respectively). BOM increased only in patients with major surgeries (p = 0.048). Significant correlations between BOM and operation time and blood loss were found (p < 0.01).ConclusionsBilirubin appears to act as an antioxidant for invasive surgery in humans. Urinary BOM could be a reliable marker for the degree of surgical stress.

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