• Mercedes Nicklasson and Bengt Bergman.
• Department of Respiratory Medicine and Allergology, Göteborg University, Gothenburg 413 45, Sweden.
• Qual Life Res. 2007 Aug 1;16(6):1019-28.

AimsTo evaluate the reliability and validity of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and LC13 questionnaire in a palliative setting, and to undertake a broad clinical evaluation of the questionnaire.PatientsOne hundred and twelve patients with advanced lung cancer or pleural mesothelioma, not amenable to curative or life-prolonging treatment, were consecutively included.MethodsConstruct validity and reliability of the EORTC questionnaire were examined by multitrait analysis and internal consistency. Criterion validity was examined by variance by and correlation with an array of clinical measures, including tumour stage, performance status, 6-min walk test, spirometry, and blood tests. Concurrent validity was evaluated by established scales for emotional distress and pain.ResultsWith the exception of cognitive functioning, reliability and construct validity of the QLQ-C30 was confirmed. Criterion and concurrent validity was supported for most of the functioning and symptom scales. In a multivariate stepwise regression analysis, EORTC physical functioning was predicted by performance status and 6-min walk distance (r (2)=.70), emotional functioning by HADS anxiety ratings (r (2)=.59), and global quality of life by performance status, HADS depression ratings, and FEV1 %predicted (r (2)=.50).ConclusionThe results support the validity and clinical relevance and of the EORTC questionnaire in a palliative setting.

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