• Psycho-oncology · Jul 2012

    Clinical validation of the EORTC QLQ-OG25 questionnaire for the evaluation of health-related quality of life in Mexican patients with esophagogastric cancers.

    • Luis F Oñate-Ocaña, Natalia Velázquez-Monroy, Luis Vázquez, Pablo Espinosa-Mireles-de-Villafranca, Elvia Núñez-Rosas, Maira Ovando-Lezama, Diana Vilar-Compte, Gabriela García-Hubard, José F Carrillo, Jane M Blazeby, and Vincenzo Aiello-Crocifoglio.
    • División de Investigación Clínica, Instituto Nacional de Cancerología, Mexico City, Mexico. lfonate@gmail.com
    • Psychooncology. 2012 Jul 1;21(7):745-53.

    BackgroundQuality of life questionnaires (QLQ) QLQ-STO22 and QLQ-OES18 are currently available to measure Health-related quality of life (HRQL) in patients with Esophageal (EC) or Gastric cancer (GC). The QLQ-OG25 integrates questions from both questionnaires to be useful for EC, Esophagogastric junction carcinoma (EGJC), and GC. Our aim was to validate the Mexican-Spanish version.Patients And MethodsThe translation procedure followed European Organization for Research and Treatment of Cancer (EORTC) guidelines. QLQ-C30 and QLQ-OG25 instruments were completed by patients with EC, EGJC, and GC. Patients were divided into three groups: (1) palliative treatment; (2) treatment with curative intent, and (3) survivors. Reliability and validity tests were performed.ResultsOne-hundred sixty-three patients were included: 62 women and 101 men (mean age, 54.9 years; range, 22-82 years). Sixty-nine, seventy-three, and twenty-one patients were allocated into groups 1, 2, and 3, respectively. Questionnaire compliance rates were high and were well accepted. Group 3 patients reported better functional HRQL scores and lower symptom scores than patients in groups 2 and 1. Scales in the QLQ-C30 and QLQ-OG25 distinguished among other clinically distinct groups of patients. Cronbach's α coefficients of all multi-item scales of the QLQ-OG25 instrument were >0.7 (range, 0.7-0.83). Multitrait scaling analysis demonstrated good convergent and discriminant validity, even adjusting by location. Test-retest scores were consistent.ConclusionThe Mexican-Spanish version of the EORTC QLQ-OG25 questionnaire is reliable and valid for HRQL measurement in patients with esophagogastric cancer and can be used in clinical trials in the Mexican community.Copyright © 2011 John Wiley & Sons, Ltd.

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