• Edward Etchells, Neill K J Adhikari, Robert Wu, Mark Cheung, Sherman Quan, Richard Mraz, Brian Wong, Ruxandra Pinto, Rajin Mehta, Dante Morra, Robert Fowler, William Sibbald, Howard Abrams, and Peter G Rossos.
• Centre for Patient Safety, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada. edward.etchells@syunnybrook.ca
• BMJ Qual Saf. 2011 Nov 1;20(11):924-30.

BackgroundFor patients with critical laboratory abnormalities, timely clinical alerts with decision support could improve management and reduce adverse events.MethodsThe authors developed a real-time clinical alerting system for critical laboratory abnormalities. The system sent alerts to physicians as text messages to a smartphone or alphanumeric pager. Decision support was available via smartphone or hospital intranet. The authors evaluated the system in a prospective controlled stepped-wedge study with blinded outcome assessment in general internal medicine units at two academic hospitals. The outcomes were the proportion of potential clinical actions that were actually completed in response to the alert, and adverse events (worsening of condition or complications related to treatment of the condition).ResultsThe authors evaluated 498 laboratory conditions on 271 patients. Overall, only 50% of potential clinical actions were carried out, and there were adverse clinical events within 48 h for 36% of the laboratory conditions. The median (IQR) proportion of potential clinical actions that were actually completed was 50% (33-75%) with alerting system on and 50% (33-100%) with alerting system off (p=0.94, Wilcoxon rank sum test). When the alerting system was on (n=164 alerts) there were 67 adverse events within 48 h of the alerts (42%). When the alerting system was off (n=334 alerts), there were 112 adverse events within 48 h (33%; difference: 9% higher with alerting system on, p=0.06).ConclusionsThe provision of real-time clinical alerts and decision support for critical laboratory abnormalities did not improve clinical management or decrease adverse events.

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