• Yvonne Lim, Alex T Sia, Kok Yuen Ho, and Alvin Teo.
• Department of Anesthesia, KK Women's and Children's Hospital, Singapore, Singapore. yvel6@hotmail.com
• Med. Sci. Monit. 2007 Jan 1;13(1):CR9-13.

BackgroundLidocaine is used as a 'test dose' to detect misplacement of epidural catheters. When administered immediately after the initiation of a combined spinal epidural for labor analgesia, it was found to interfere with motor function. The authors hypothesized that an epidural test dose of 3 ml of 1.5% lidocaine injected immediately after the initiation of combined spinal epidural analgesia and followed by a continuous epidural infusion would prolong the duration of analgesia and decrease the incidence of breakthrough pain.Material/MethodsSixty nulliparous parturients were recruited for this randomized controlled trial. Combined spinal epidural analgesia was performed with intrathecal levobupivacaine 2.5 mg and fentanyl 25 microg. The patients were randomized into three groups: group L receiving 3 ml of 1.5% epidural lidocaine, group S 3 ml of normal saline, and group C the control group receiving no test solution. An epidural infusion of 0.1% levobupivacaine and 2 microg of fentanyl/ml at 10 ml/hr was initiated immediately. Their need for supplementary analgesia, duration of analgesia, sensory block, motor block, side-effects, and overall satisfaction were recorded.ResultsThe breakthrough pain rate in all groups were similar. Their mean duration of analgesia (mean survival times) were not significantly different. Group C had the lowest incidence of lower limb motor block. The satisfaction scores were significantly highest in group L.ConclusionsThe administration of epidural lidocaine and saline immediately after intrathecal levobupivacaine 2.5 mg and fentanyl 25 microg did not reduce the incidence of breakthrough pain in combined spinal epidural labor.

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