• Epileptic Disord · Dec 2009

    Case Reports

    Acetaminophen toxicity with concomitant use of carbamazepine.

    • Glen Jickling, Angela Heino, and S Nizam Ahmed.
    • University of Alberta Hospital, Alberta, Canada.
    • Epileptic Disord. 2009 Dec 1;11(4):329-32.

    AbstractAcetaminophen is a widely used analgesic that can cause acute liver failure when consumed above a maximum daily dose. Certain patients may be at increased risk of hepatocellular damage even at conventional therapeutic doses. We report a case of a 34-year-old man on carbamazepine for complex partial seizures who developed acute liver and renal failure on less than 2.5 grams a day of acetaminophen. This raises caution that patients on carbamazepine should avoid chronic use of acetaminophen, and if required use at lower doses with vigilant monitoring for signs of liver damage.

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