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Case Reports
Two cases of ampulla (takotsubo-shaped) cardiomyopathy associated with hemophagocytic lymphohistiocytosis.
- Yasunobu Takeoka, Mika Nakamae, Hirohisa Nakamae, Kiyoyuki Hagihara, Erina Sakamoto, Takahiko Nakane, Hideo Koh, Ki-Ryang Koh, Kensuke Ohta, Takahisa Yamane, and Masayuki Hino.
- Clinical Hematology and Clinical Diagnostics, Graduate School of Medicine, Osaka City University, Osaka, Japan. takeoka@med.osaka-cu.ac.jp
- Acta Haematol. 2007 Jan 1;117(4):205-10.
AbstractThere have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with hemophagocytic lymphohistiocytosis (HLH). In both of the patients, ventricular dysfunction suddenly occurred during the active phase of HLH. In each case, the findings on ECG, echocardiogram and left ventriculogram were compatible with ampulla cardiomyopathy. To our knowledge, this communication is the first to report cases of ampulla cardiomyopathy associated with HLH. Our cases suggest that HLH hypercytokinemia may have a role in causing ampulla cardiomyopathy.2007 S. Karger AG, Basel
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