• J Arthroplasty · Feb 2014

    Celecoxib and heterotopic bone formation after total hip arthroplasty.

    • Carlos J Lavernia, Juan S Contreras, Jesus M Villa, and Mark D Rossi.
    • Orthopaedic Institute at Mercy Hospital, Miami, Florida.
    • J Arthroplasty. 2014 Feb 1;29(2):390-2.

    AbstractWe assessed the effectiveness of celecoxib in the prevention of heterotopic ossification (HO) following primary total hip replacement (THR). We studied 170 consecutive THRs. Sixty-three patients received celecoxib after surgery (200mg twice/daily) for 28 days and 84 did not. HO was more common in non-celecoxib patients than in the celecoxib-group at 3, 6, and 12 months (P =0.005, 0.004 and 0.01, respectively). At 1 year, fewer celecoxib recipients had Brooker classes II or III. None of the celecoxib patients developed HO Brooker class IV, while 2% in the non-celecoxib group did. No patient discontinued treatment or had revision for aseptic loosening. A short course of celecoxib for pain aids in the prevention of HO after primary THR, and could be a useful and safe option that does not interfere with anticoagulation.© 2014.

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