• J Clin Neurosci · Feb 2005

    Comparative Study

    CSF spectrophotometry in the diagnosis and exclusion of spontaneous subarachnoid haemorrhage.

    • M J Wood, G Dimeski, and A M Nowitzke.
    • Department of NeurosurgeryPrincess Alexandria Hospital, Brisbane, QLD, Australia.
    • J Clin Neurosci. 2005 Feb 1;12(2):142-6.

    AimsTo assess the sensitivity and specificity of CSF spectrophotometry for the detection of xanthochromia in patients with clinical symptoms suggestive of subarachnoid haemorrhage (SAH) but normal cranial computed tomography (CT).MethodsAll consecutive patients undergoing both cranial CT and lumbar puncture for investigation of possible SAH at the Princess Alexandra Hospital, Brisbane, between January 2000 and April 2003 were included in the study. All case histories, radiology and laboratory results were retrospectively assessed. The sensitivity, specificity and positive predictive value of the spectrophotometry test were calculated.Results253 patients were included in the study. Spectrophotometry was shown to have a sensitivity of 100% but a specificity of only 75.2%. The positive predictive value of spectrophotometry as an indicator of SAH was 3.3%.ConclusionsCSF spectrophotometry has an unacceptably low specificity and positive predictive value, which greatly limit its use as a clinical tool.

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