• J Geiseler and O Karg.
• Klinik für Intensivmedizin und Langzeitbeatmung, Asklepios Fachkliniken München-Gauting, Zentrum für Pneumologie und Thoraxchirurgie München-Gauting. j.geiseler@asklepios.com
• Pneumologie. 2007 Aug 1;61(8):531-5.

AbstractAcute ventilatory insufficiency is characterized by hypercapnia, respiratory acidosis and secondary hypoxemia. The primary target of mechanical ventilation is improvement of alveolar ventilation, that means compensation of the ventilatory insufficiency. Noninvasive ventilation started as ventilatory support during the big polio epidemic, at that time in form of negative pressure ventilation. In the last two decades NIV is in form of positive pressure ventilation important for long-term ventilation at home, but there is also growing importance of NIV in the treatment of acute respiratory insufficiency in the intensive care unit. Main indication is the hypercapnic ventilatory failure in acute exacerbation of COPD. This paper will discuss ventilator therapy in general but also the data regarding the role of NIV in the treatment of hypercapnic failure. Specific points like interfaces, indications and contraindications of NIV are addressed.

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